Pentad of Thrombotic Thrombocytopenic Purpura (TTP):

shared by Shadi Haddad

Mnemonic: "The Father Must Never Know"

T: Thrombocytopenia, bruising 

F: Fever
M: Microangiopathic Hemolytic Anemia
N: Neurologic Symptoms (Headache, stroke, confusion)
K: Kidney failure.

CREST Syndrome

Calcinosis - Ca deposits under skin, esp. in fingers, elbows & kness
Raynaud's phenomenon - Purplish color change/pain/numbness in fingers after cold/stress
Esophageal dysfunction - difficult swallowing
Sclerodactyly - thick, hard, shiny, taut skin esp. in extremities
Telangiectasias - usually on face, hands, lips, intestinal lining

CAUSES OF EXFOLIATIVE DERMATITIS

RED MAN
Radiation    Eczema/psoriasis    Drugs    Malignancy (MF, lymphoma)    Autoimmune (rare DM)    No cause found (Idiopathic)

CHEDIAK-HIGASHI SYNDROME

	HIGASHI
Hair, silver    Immune Deficiency    orGanelle-Lysosome    Anemia, thrombocytopenia, leukopenia    Seizures, CNS    pHotophobia    Inclusions-giant, azure

PAINFUL TUMOURS OF THE SKIN

BENGAL
Blue rubber bleb nevus    Eccrine spiradenoma    Neuroma    Glomus tumor    Angiolipoma    Leiomyoma

Lichen planus characteristics

 Planus has 4 P's:
Peripheral
Polygonal
Pruritus
Purple

BEHCET'S SYNDROME: DIAGNOSTIC CRITERIA

Pathergy Test
Recurrent genital ulceration
Oral ulceration (recurrent)
Skin lesions (e.g. erythema nodosum, subcutaneous thrombophlebitis,
Eye lesions (e.g. iridocyclitis, chorioretinitis)

MODIFIED CRITERIA FOR THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

Antinuclear antibody
Neurologic disorder- seizures or psychosis
Thrombocytopenia or lymphopenia or leukopenia or hemolytic anemia
Immunologic disorder- positive lupus erythematosus cell prep. or anti-ds DNAor
Nasopharyngeal or oral ulcers
Urinary abnormalities - proteinuria or casts
Cutaneous discoid rash
Light sensitivity
Effusions-pleuritis or pericarditis
Arthritis of two or more joints
Rash in malar area

Black eschar differential

Clostridium
Aspergillus ( Deep Fungal e.g. fusarium)/Anthrax
Group B strep
Ecthyma gangrenosum - pseudomonas
Spider bite

DAPSONE treated conditions

Dermatitis herpetiformis
IgA, linear
Pemphigus / Pyoderma Gangrenosum
SLE, bullous variant
Other (Eosinophilic, Monocyctic)
Neutrophilic dermatoses / Vasculitis / HSP
Erythema Elevatum Diutinum

PSORIATIC ARTHRITIS - 5 TYPES

	SODAS
Spondylitis or Sacroiliac    Oligoarticular    Distal joint    Arthritis mutilans    Symmetric poylarthritis

PAINFUL SOLITARY DERMAL NODULES

	TANGLED
Traumatic neuroma    Angiolipoma    Neurilemmuma    Glomus tumor    Leiomyoma    Eccrine spiradenoma    Dercums disease (Adiposis Dolorosa)

NON-SCARRING ALOPECIA

	TOP HAT
Telogen effluvium, Tinea capitis    Out of iron, zinc    Physical - trichotillomania, traction alopecia    Hormonal - hypothyroidism, androgenic    Autoimmune - alopecia areata, anagen effluvium    Toxins - heavy metals, chemotherapy

MULTIPLE LENTIGINES SYNDROME

	CLAMP
Centrofacial Lentiginosis    LEOPARD Syndrome    Adolescent Eruptive Len.    Moynahan's Syndrome    Peutz-Jegher's

MIXED CONNECTIVE TISSUE DISEASE, SKIN MANIFESTATION

	SMEAR
Scleroderma    Myositis    Edema    Acrosclerosis    Raynauds

MENKES KINKY HAIR SYNDROME

	MENKES
MEN (XLR), MNK gene which encodes for a CU++-transporting APTase    Early death    pNeumonia (and other infections), trichorehexis Nodosa (may be seen)    Kinky hair (pili torti) -+ pili torti is more common than TN    Extra skin on palms (degen'd vessel elastic tissue)    Seizures, Skeletal changes

MELANOMA RISKS

	MMRISK
Moles that are atypical or dysplastic nevi    Moles that are many in number    Red hair    Inability to tan    Sunburn (especially severe burns before age 14)    Kindred (family history)

ICHTHYOSIS

	CORNERS
CO - Conradi's    Rud's    Netherton's    Erythrokeratoderma Variabilis    Refsum's    Sjogren-Larsson

DISEASES WITH ANGIOID STREAKS

	APPLES
Acromegally    Pseudoxanthoma elasticum    Paget's disease    Lead poisoning    Ehlers-Danlos syndrome    Sickle cell anemia

DERMATOMYOSITIS

	MUSCLE PAINS
Malignancy (breast, lung, ovary, GI)    Ungual telangiectasias    Subcutaneous calcinosis    Cardiac    Liver    Eyes (heliotrope lids, photosensitivity, retinopathy)    Poikiloderma / Polyarthritis    Aldolase    Interstitial pneumonitis    Needle biopsy    Sclerodermatomyositis