Xylocaine: Where not to use with Adrenaline?

"Digital PEN"

• Digits (Fingers and toes)
• Penis
• Ear
• Nose tip

Adrenaline causes vasoconstriction which helps to trap Xylocaine (anaesthetic) locally prolonging its duration of action. The two are not used together at sites supplied by end arteries as the vasoconstriction produced by adrenaline can cause ischemic necrosis of the tissues.

Adrenaline is also referred to as Epinephrine.