In memory of Ronald Reagen (former US president) who was a victim of AD.
- Reduction of acetylcholine
- Old age
- Navigational difficulty, Neurofibrillary tangles (NFTs)
- Atrophy of cerebral cortex(diffuse)
- Language impairment
- Dementia, Delusions
The cognitive changes in AD follows a characteristic pattern, beginning with memory impairment and progressing to language (naming, comprehension and finally fluency) and visuospatial deficits.
The most severe pathology is usually found in the hippocampus, temporal cortex and nucleus basalis of Meynert (lateral septum).
Microscopically, the most important finding is "senile" plaques and NFTs (neurofibrillary tangles) found in excess than in a normal aging brain.
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