Drugs metabolized by acetylation

SHIP'

• Sulfonamides including dapsone
• Hydralazine
• Isoniazid (INH)
• Procainamide

Acetylator polymorphism:Some individuals are slow acetylators and some are fast acetylators.The drugs metabolized by acetylation may become ineffective in fast acetylators and cause toxicity in slow acetylators.